甲状腺功能减退和甲状腺功能亢进对实验大鼠血清糖蛋白的影响。
Effects of hypothyroidism and hyperthyroidism on serum glycoproteins in experimental rats.
作者信息
Uniyal B P, Singh L R, Nagpal K K
机构信息
Institute of Nuclear Medicine & Allied Sciences, Lucknow Marg, Delhi, India.
出版信息
Indian J Exp Biol. 1998 Feb;36(2):148-51.
Hypothyroidism and hyperthyroidism were induced in adult female Sprague Dawley rats by feeding 0.05% propylthiouracil and 0.0012% L-thyroxine in drinking water. Contents of protein-bound hexose, fucose, hexosamine and sialic acid in serum were estimated in experimental rats. The results showed an increase in the protein bound hexose, fucose, hexosamine and sialic acid levels in hypothyroid rats and decrease in hyperthyroid rats. The increased content of serum glycoproteins in hypothyroid rats might possibly have come from disruptions of membranes. Depleted glycoproteins in hyperthyroid animals might be due to increase in depolymerisations of glycoproteins and accelerated secretion of glycoproteins with urine.
通过在成年雌性斯普拉格-道利大鼠的饮用水中添加0.05%的丙硫氧嘧啶和0.0012%的L-甲状腺素，诱导大鼠出现甲状腺功能减退和甲状腺功能亢进。对实验大鼠血清中蛋白结合己糖、岩藻糖、氨基己糖和唾液酸的含量进行了测定。结果显示，甲状腺功能减退大鼠的蛋白结合己糖、岩藻糖、氨基己糖和唾液酸水平升高，而甲状腺功能亢进大鼠的这些指标则降低。甲状腺功能减退大鼠血清糖蛋白含量的增加可能源于细胞膜的破坏。甲状腺功能亢进动物中糖蛋白的减少可能是由于糖蛋白解聚增加以及糖蛋白随尿液加速分泌所致。
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