Singh R K, Nath G, Goel R K, Bhattacharya S K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1998 Feb;36(2):187-91.
Petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanolic (EE) extracts (50-200 or 200 mg/kg, i.p. or 200 mg/kg, p.o.) of dried Abies pindrow leaves, given 30-45 min before showed significant anti-inflammatory (both against acute and sub-acute models), analgesic, barbiturate hypnosis potentiation and anti-ulcerogenic acitivities in rats. All the extracts except EE decreased swim stress immobility in mice indicating some degree of anti-depressant activity. Only PE exhibited hypotension in dogs blocked by atropine. Chemically, extracts showed the presence of glycosides, steroids, terpenoids and flavonoids. They had no anti-bacterial effect. However, toxicity studies indicated that the extracts had an extended safety index. The investigations are consonant with some of the uses of this plant in Ayurveda.
