Gannagé-Yared M H, Khneisser I, Salem N, Gouyette A, Loiselet J, Halaby G, Massade L
Département d'endocrinologie, Faculté de médecine de l'Université Saint-Joseph, Beyrouth, Liban.
Ann Biol Clin (Paris). 1998 May-Jun;56(3):321-7.
Hypercholesterolemia increases the oxidation of low density lipoprotein (LDL) which subsequently leads to atherogenesis. The oxidized LDL are also known to increase in vitro macrophage synthesis of glutathione. The purpose of this study was to investigate the relationship between lipid parameters and the glutathione system (glutathione, glutathione S-transferase) in total blood and within leukocytes. The glutathione and glutathione S-transferase were evaluated by spectrophotometric methods in sixty-two healthy volunteers (32 women, 30 men, mean age 39.9 +/- 7.7). No correlation was found between the level of blood cholesterol and the values of the blood glutathione system. However, a positive correlation between the values of glutathione and glutathione S-transferase in leukocytes and the blood cholesterol level was only found in women (r = 0.55 and r = 0.50 respectively, p < 0.01). We also found in men a positive correlation between body mass index and glutathione S-transferase in total blood and within leukocytes (r = 0.38, p < 0.05, r = 0.5, p < 0.01 respectively). No correlation was found between age, smoking and the values of the glutathione system. Our results suggest that the glutathione system in leukocytes is related to blood cholesterol levels. The fact that this positive correlation was only observed in women points to a possible role of estrogens in the regulation of the glutathione system which merits to be further studied.
高胆固醇血症会增加低密度脂蛋白（LDL）的氧化，进而导致动脉粥样硬化的发生。氧化型LDL还已知会在体外增加巨噬细胞中谷胱甘肽的合成。本研究的目的是调查总血及白细胞内脂质参数与谷胱甘肽系统（谷胱甘肽、谷胱甘肽S转移酶）之间的关系。通过分光光度法对62名健康志愿者（32名女性，30名男性，平均年龄39.9±7.7岁）的谷胱甘肽和谷胱甘肽S转移酶进行了评估。未发现血胆固醇水平与血谷胱甘肽系统的值之间存在相关性。然而，仅在女性中发现白细胞内谷胱甘肽和谷胱甘肽S转移酶的值与血胆固醇水平呈正相关（分别为r = 0.55和r = 0.50，p < 0.01）。我们还发现男性的体重指数与总血及白细胞内的谷胱甘肽S转移酶呈正相关（分别为r = 0.38，p < 0.05，r = 0.5，p < 0.01）。未发现年龄、吸烟与谷胱甘肽系统的值之间存在相关性。我们的结果表明，白细胞内的谷胱甘肽系统与血胆固醇水平有关。仅在女性中观察到这种正相关这一事实表明雌激素在谷胱甘肽系统的调节中可能起作用，这值得进一步研究。
