Foulon T, Laporte F, Payen N, Groslambert P
Laboratoire de Biochimie A, CHU de Grenoble.
Ann Biol Clin (Paris). 1998 Jul-Aug;56(4):451-6.
Reference ranges for apolipoprotein AI and B plasma concentrations were established in a population of unrelated apparently healthy volunteers (138 men and 186 women) living in the region of Grenoble. Apolipoproteins were measured using an immunoturbidimetric assay on a Cobas Fara II analyzer, with reagents and IFCC standardized calibrators from Orion. Apolipoprotein AI mean concentration was higher in women than in men and increased with age in both men and women older than 45. Apolipoprotein B mean concentration was higher in men and increased linearly with age in both sexes. Linear regression analysis was used to determine desirable and high risk values for apolipoproteins AI and B from the guidelines developed by the National Cholesterol Education Program for HDL cholesterol and LDL cholesterol, respectively. Our data indicate that an apolipoprotein AI value of 1.05 g/l is comparable to an HDL cholesterol value of 0.35 g/l. The apolipoprotein B cutpoints of 1.15 g/l for men and 1.05 g/l for women correspond to the accepted LDL cholesterol cutpoint of 1.60 g/l.
在格勒诺布尔地区生活的一群无亲缘关系、外表健康的志愿者（138名男性和186名女性）中确定了载脂蛋白AI和B血浆浓度的参考范围。使用免疫比浊法在Cobas Fara II分析仪上测量载脂蛋白，所用试剂和IFCC标准化校准品来自奥立龙公司。女性的载脂蛋白AI平均浓度高于男性，且45岁以上的男性和女性其浓度均随年龄增长而升高。男性的载脂蛋白B平均浓度较高，且在两性中均随年龄呈线性增加。分别根据美国国家胆固醇教育计划制定的高密度脂蛋白胆固醇和低密度脂蛋白胆固醇指南，采用线性回归分析来确定载脂蛋白AI和B的理想值和高风险值。我们的数据表明，载脂蛋白AI值为1.05 g/l相当于高密度脂蛋白胆固醇值为0.35 g/l。男性载脂蛋白B的切点为1.15 g/l，女性为1.05 g/l，这与公认的低密度脂蛋白胆固醇切点1.60 g/l相对应。
