Vella J C, Calmarza P
Hospital General Yagüe, Burgos, Espagne.
Ann Biol Clin (Paris). 1998 Jul-Aug;56(4):457-61.
We have studied the concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol, apolipoproteins A-I and B, and lipoprotein (a) in cord blood, from children born in our hospital for a five-month period. Cholesterol and triglycerides values were slightly lower than values obtained in cord blood within other populations. The distribution of lipoprotein (a) concentrations was markedly skewed towards low values (mean = 1.74 mg/dl, median = 1 mg/dl), similar to that of other young or adult Caucasian populations. Children with a positive familial history of cardiovascular heart disease had a higher mean lipoprotein level (a), and a higher prevalence of lipoprotein values exceeding 5 mg/dl, than children with a negative familial history. These results suggest that lipoprotein (a) is an important risk factor for cardiovascular heart disease.
我们对我院出生的婴儿在五个月期间的脐带血中的胆固醇、甘油三酯、高密度脂蛋白胆固醇、载脂蛋白A-I和B以及脂蛋白(a)的浓度进行了研究。胆固醇和甘油三酯值略低于其他人群脐带血中的值。脂蛋白(a)浓度的分布明显偏向低值（平均值 = 1.74毫克/分升，中位数 = 1毫克/分升），与其他年轻或成年白种人群相似。有心血管疾病家族史阳性的儿童比家族史阴性的儿童平均脂蛋白(a)水平更高，且脂蛋白值超过5毫克/分升的患病率更高。这些结果表明脂蛋白(a)是心血管疾病的一个重要危险因素。
