Hofman P, Battaglione V
Laboratoire d'Anatomie Pathologique, Hôpital Pasteur, Nice, France.
Arch Anat Cytol Pathol. 1998;46(1-2):141-4.
Epithelial tumors with thymus-like differentiation occurring in the thyroid gland and the neck, delineate four entities with distinct histological features and different behaviour. The spindle epithelial tumors with thymus-like differentiation are potentially malignant tumors occurring in the thyroid gland of young patients. They are highly cellular with pattern of spindle cells and tubulopapillary formations and mucinous glands. Carcinomas showing thymus-like differentiation of the thyroid gland are histologically identical to some thymic carcinomas. The ectopic hamartomatous thymoma is strictly benign and occurs in the soft tissues of the lower neck. It is characterized by spindle and solid or cystic islands of epithelial cells associated with adipose cells. The ectopic cervical thymoma is usually benign and histologically similar to mediastinal thymomas. All these tumors are particularly rare and arise from ectopic thymus or remnants of branchial pouch. The differential diagnoses of these tumors can be difficult and include some other proliferations occurring in the neck.
发生于甲状腺和颈部的具有胸腺样分化的上皮性肿瘤，可分为四种具有不同组织学特征和行为的实体。具有胸腺样分化的梭形上皮肿瘤是发生于年轻患者甲状腺的潜在恶性肿瘤。它们细胞丰富，具有梭形细胞、管状乳头结构和黏液腺的形态。甲状腺显示胸腺样分化的癌在组织学上与某些胸腺癌相同。异位错构瘤性胸腺瘤严格来说是良性的，发生于下颈部软组织。其特征为上皮细胞的梭形及实性或囊性岛状结构，并伴有脂肪细胞。异位颈部胸腺瘤通常为良性，组织学上与纵隔胸腺瘤相似。所有这些肿瘤都极为罕见，起源于异位胸腺或鳃囊残余。这些肿瘤的鉴别诊断可能困难，包括颈部发生的一些其他增殖性病变。
