The Department of Medical Oncology, Cancer Center State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan 610041, China.
Pathol Res Pract. 2013 Oct;209(10):662-5. doi: 10.1016/j.prp.2013.06.021. Epub 2013 Jul 15.
Carcinoma showing thymus-like differentiation (CASTLE) is a rare intrathyroidal neoplasm, probably arising from ectopic thymus or branchial pouch remnants. The tumor was first reported by Miyauchi et al. [1].The clinical and pathological features of this tumor were classified by Chan et al. [2] into 4 groups: ectopic hamartomatous thymoma, ectopic cervical thymoma, spindle ephithelial tumor with thymic-like differentiation (SETTLE), and carcinoma showing thymus-like differentiation (CASTLE). Recently, CASTLE has been designated as an independent clinicopathologic entity of thyroid tumors in the most recent edition of the World Health Organization classification of tumors of endocrine organs[3].To our knowledge, less than 100 cases of CASTLE have been reported in the literature, 45 cases of which (including one of the authors' patient) have been identified in China. We report a new case of this entity and suggest recommendations for diagnosis.
癌，具有胸腺样分化（CASTLE）是一种罕见的甲状腺内肿瘤，可能来源于异位胸腺或鳃裂囊残余。该肿瘤由 Miyauchi 等人首次报道[1]。Chan 等人[2]根据该肿瘤的临床和病理特征将其分为 4 组：异位错构性胸腺瘤、异位颈胸腺瘤、具有胸腺样分化的梭形上皮肿瘤（SETTLE）和癌，具有胸腺样分化（CASTLE）。最近，CASTLE 在世界卫生组织内分泌器官肿瘤分类的最新版本中被指定为甲状腺肿瘤的独立临床病理实体[3]。据我们所知，文献中报道的 CASTLE 病例不到 100 例，其中 45 例（包括作者之一的患者）在中国被发现。我们报告了该实体的一个新病例，并提出了诊断建议。
