Rossi M, Vannuccini L
U.O. Pneumologia USL 8, Arezzo, Italy.
Technol Health Care. 1998 Jun;6(1):91-7.
The aim of this study was to analyse inspiratory crackles in patients with Pulmonary Fibrosis (PF) and Bronchiectasis (BE). One case of Chronic Obstructive Pulmonary Disease (COPD) has also been included. The relationships between the time of occurrence of crackles (T) in the breath cycle and the corresponding flow at the mouth (F) and volume (V) have been investigated. The linear correlations between the flow, volume and time have been investigated by Pearson's R-test and the same variables have been analysed by Principal Component Analysis (PCA) in order to verify the effective dimension of these data. The results show a strong correlation between the time of occurrence and the volume in all the examined cases. PCA shows that in all cases F and V account for more than 90% of variation. These results suggest that placing crackles on the flow-volume plane does not cause loss of information.
本研究旨在分析肺纤维化（PF）和支气管扩张（BE）患者的吸气性啰音。还纳入了1例慢性阻塞性肺疾病（COPD）患者。研究了呼吸周期中啰音出现时间（T）与相应的口腔气流（F）和容积（V）之间的关系。通过Pearson相关系数R检验研究了气流、容积和时间之间的线性相关性，并通过主成分分析（PCA）对相同变量进行分析，以验证这些数据的有效维度。结果显示，在所有检查病例中，啰音出现时间与容积之间存在很强的相关性。主成分分析表明，在所有病例中，F和V占变异的90%以上。这些结果表明，将啰音置于流速-容积平面上不会导致信息丢失。
