Serretti A, Macciardi F, Di Bella D, Catalano M, Smeraldi E
Istituto Scientifico H. San Raffaele, Department of Neuroscience, University of Milan, School of Medicine, Milano, Italy.
Psychiatry Res. 1998 Aug 17;80(2):137-44. doi: 10.1016/s0165-1781(98)00065-1.
Disturbances of the dopaminergic and serotoninergic neurotransmitter systems have been implicated in the pathogenesis of depressive symptoms. Associations have been reported between markers of the two neurotransmitter systems and the presence of illness or severity of depressive episodes, but no attention has been focused on the periods of remission. The present report focuses on a possible association of self-esteem in remitted mood disorder patients with the functional polymorphism located in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the dopamine receptor D4 (DRD4). Inpatients (N=162) affected by bipolar (n=103) and unipolar (n=59) disorder (DSM III-R) were assessed by the Self-Esteem Scale (SES, Rosenberg, 1965) and were typed for DRD4 and 5-HTTLPR (n=58 subjects) variants at the third exon using polymerase chain reaction (PCR) techniques. Neither DRD4 nor 5-HTTLPR variants were associated with SES scores, and consideration of possible stratification effects such as sex and psychiatric diagnosis did not reveal any association either. The serotonin transporter and dopamine receptor D4 genes do not, therefore, influence self-esteem in remitted mood disorder subjects.
多巴胺能和血清素能神经递质系统的紊乱与抑郁症状的发病机制有关。已有报道称，这两种神经递质系统的标志物与疾病的存在或抑郁发作的严重程度之间存在关联，但尚未有人关注缓解期。本报告重点关注缓解期心境障碍患者的自尊与位于血清素转运体基因（5-HTTLPR）上游调控区和多巴胺受体D4（DRD4）的功能多态性之间可能存在的关联。采用自尊量表（SES，Rosenberg，1965）对162名双相（n = 103）和单相（n = 59）障碍（DSM III-R）住院患者进行评估，并使用聚合酶链反应（PCR）技术对其DRD4和5-HTTLPR（n = 58名受试者）在第三个外显子处的变体进行分型。DRD4和5-HTTLPR变体均与SES评分无关，考虑性别和精神诊断等可能的分层效应也未发现任何关联。因此，血清素转运体基因和多巴胺受体D4基因不会影响缓解期心境障碍患者的自尊。
