Manki H, Kanba S, Muramatsu T, Higuchi S, Suzuki E, Matsushita S, Ono Y, Chiba H, Shintani F, Nakamura M, Yagi G, Asai M
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
J Affect Disord. 1996 Sep 9;40(1-2):7-13. doi: 10.1016/0165-0327(96)00035-3.
Disturbances in dopaminergic systems have been implicated in the etiology of mood disorders. Although genetic factors also play an important role, no major gene has been identified. We conducted an association study using the dopamine D2, D3 and D4 receptor, and transporter gene polymorphisms, comparing 101 mood-disorder patients (52 bipolar and 49 unipolar) and 100 controls. Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.
多巴胺能系统紊乱与情绪障碍的病因有关。尽管遗传因素也起重要作用，但尚未发现主要基因。我们使用多巴胺D2、D3和D4受体以及转运体基因多态性进行了一项关联研究，比较了101名情绪障碍患者（52名双相情感障碍患者和49名单相情感障碍患者）和100名对照。我们的结果表明，多巴胺D4受体基因与情绪障碍之间存在显著关联，尤其是重度抑郁症，但其他多态性与情绪障碍之间无关联。需要进一步研究以阐明这种关联在情绪障碍病理生理学中的临床意义。
