Smith V C, Sagot M A, Couraud J Y, Buchan A M
Department of Physiology, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1998 Aug 28;253(1):49-52. doi: 10.1016/s0304-3940(98)00618-1.
A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum.
一种新获得的针对神经激肽-1受体（NK-1r）的抗体使得确定NK-1r受体在人体组织中的分布成为可能。在本研究中，通过免疫细胞化学方法确定了NK-1r和P物质在人胃窦和十二指肠中的分布。NK-1r存在于胃肠神经系统的肌间和黏膜下神经元及神经纤维上。此外，该受体还存在于环形肌层的梭形细胞、内皮细胞和一群黏膜细胞上。在黏膜下神经丛中，NK-1r免疫反应性神经元被含P物质的纤维所包围。这些结果表明NK-1r在人胃窦和十二指肠中存在广泛的细胞表达。
