Sulter G, Elting J W, De Keyser J
Department of Neurology, Academisch Ziekenhuis Groningen, The Netherlands.
Neurosci Lett. 1998 Aug 28;253(1):71-3. doi: 10.1016/s0304-3940(98)00595-3.
A detrimental effect of hyperglycemia in ischemic brain has been demonstrated in laboratory experiments and it has been found that hyperglycemia in ischemic stroke is a predictor of poor outcome. We determined serum neuron specific enolase (NSE) concentrations in 41 consecutive patients with a cerebral hemispheric stroke between 12 and 24 h after stroke onset. In cortical ischemic strokes complicated by hyperglycemia (blood glucose concentration > 7 mmol/l) we found significantly higher NSE levels than in normoglycemic patients. In lacunar ischemic strokes NSE levels were not significantly different between normoglycemic and hyperglycemic patients. Our findings support the concept that hyperglycemia during acute cortical ischemic stroke is associated with enhanced neuronal cell death.
实验室实验已证实高血糖对缺血性脑具有有害作用，并且发现缺血性卒中时的高血糖是预后不良的一个预测指标。我们测定了41例连续性大脑半球卒中患者在卒中发作后12至24小时之间的血清神经元特异性烯醇化酶（NSE）浓度。在合并高血糖（血糖浓度>7 mmol/L）的皮质缺血性卒中患者中，我们发现其NSE水平显著高于血糖正常的患者。在腔隙性缺血性卒中患者中，血糖正常和高血糖患者之间的NSE水平无显著差异。我们的研究结果支持这样的观点，即急性皮质缺血性卒中期间的高血糖与神经元细胞死亡增加有关。
