非铜绿假单胞菌革兰氏阴性非发酵菌对环丙沙星、氧氟沙星、左氧氟沙星、D-氧氟沙星、司帕沙星、头孢他啶、哌拉西林、哌拉西林-他唑巴坦、甲氧苄啶-磺胺甲恶唑和亚胺培南的敏感性。
Susceptibilities of non-Pseudomonas aeruginosa gram-negative nonfermentative rods to ciprofloxacin, ofloxacin, levofloxacin, D-ofloxacin, sparfloxacin, ceftazidime, piperacillin, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, and imipenem.
作者信息
Spangler S K, Visalli M A, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 1996 Mar;40(3):772-5. doi: 10.1128/AAC.40.3.772.
Abstract
Agar dilution MICs of 10 agents against 410 non-Pseudomonas aeruginosa gram-negative nonfermentative rods were determined. MICs at which 50 and 90% of the isolates were inhibited, respectively, were as follows (in micrograms per milliliter): sparfloxacin, 0.5 and 8.0; levofloxacin, 1.0 and 8.0; ciprofloxacin, 2.0 and 32.0; ofloxacin, 2.0 and 32.0; D-ofloxacin, 32.0 and > 64.0; ceftazidime, 8.0 and 64.0; piperacillin with or without tazobactam, 16.0 and > 64.0; trimethoprim-sulfamethoxazole, 0.5 and > 64.0; imipenem, 2.0 and > 64.0. With the exception of those for Stenotrophomonas maltophilia, Burkholderia cepacia, and Alcaligenes faecalis-A. odorans, agar dilution MICs for all strains tested were within 1 dilution of inhibitory (bacteriostatic) levels as determined by time-kill methodology.
摘要
测定了10种药物对410株非铜绿假单胞菌革兰氏阴性非发酵菌的琼脂稀释法最低抑菌浓度（MIC）。分别使50%和90%的分离株受到抑制的MIC如下（以微克/毫升计）：司帕沙星，0.5和8.0；左氧氟沙星，1.0和8.0；环丙沙星，2.0和32.0；氧氟沙星，2.0和32.0；D-氧氟沙星，32.0和>64.0；头孢他啶，8.0和64.0；哌拉西林（无论是否联用他唑巴坦），16.0和>64.0；复方磺胺甲恶唑，0.5和>64.0；亚胺培南，2.0和>64.0。除嗜麦芽窄食单胞菌、洋葱伯克霍尔德菌和粪产碱菌-嗜臭产碱菌外，所有受试菌株的琼脂稀释法MIC均在通过时间杀菌法测定的抑菌（抑菌）水平的1个稀释度范围内。
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