Calès P
Service d'Hépato-Gastroentérologie, Centre Hospitalier Universitaire, Angers, France.
Biomed Pharmacother. 1998;52(6):259-63. doi: 10.1016/S0753-3322(98)80011-5.
Hepatic fibrosis is a frequent response of the liver and is similar to parenchymal wound healing in other tissues. Apoptosis has been described in different models of liver fibrosis. Hepatic stellate cells are the main source of extracellular matrix. At present, one can speculate that inhibition of apoptosis is responsible for activation and proliferation of hepatic stellate cells. Thus, the inhibition of hepatic stellate cell apoptosis could be a target for antifibrotic strategies. Until now, no drugs have been clearly shown to be effective in reducing specifically the development of hepatic fibrosis. However, serious candidates are presently under studies in clinical trials, including especially alpha interferon and phosphatidylcholine.
肝纤维化是肝脏常见的反应，与其他组织中的实质伤口愈合相似。在不同的肝纤维化模型中均已描述了细胞凋亡。肝星状细胞是细胞外基质的主要来源。目前，可以推测细胞凋亡的抑制是肝星状细胞激活和增殖的原因。因此，抑制肝星状细胞凋亡可能是抗纤维化策略的一个靶点。到目前为止，尚无药物被明确证明能有效特异性地减少肝纤维化的发展。然而，目前有几种有望成功的药物正在临床试验中进行研究，尤其是α干扰素和磷脂酰胆碱。
