Yamazaki H, Nishimoto N, Oi H, Matsushita M, Ogata A, Shima Y, Inoue T, Tang J T, Yoshizaki K, Kishimoto T
Department of Radiation Oncology, Osaka University Medical School, Japan.
Cytokine. 1995 Feb;7(2):191-5. doi: 10.1006/cyto.1995.1026.
To evaluate the value of serum interleukin 6 (sIL-6) for the prediction of therapeutic effect and adverse reaction after transcatheter arterial embolization (TAE), sIL-6 was measured before and after angiography or TAE in 18 patients (three after angiography and 15 after TAE for hepatocellular carcinoma). The three patients with only angiography showed no elevation of sIL-6, while a significant increase was observed after TAE in the 15 hepatocellular carcinoma patients. The sIL-6 levels of patients with a partial response to TAE were higher at 48-72 hours after the procedure than those of patients with no response (P = 0.045), and the sIL-6 levels of patients who showed adverse reactions were higher at 6-24 h than those of patients without adverse reactions (P = 0.019). sIL-6 level at 48-72 h after TAE reflects the efficacy of TAE, whereas the level at 6-24 h after TAE is related to the severity of adverse reactions. Therefore, sIL-6 may be a useful indicator for prediction of the therapeutic effect of TAE as well as adverse reactions.
为评估血清白细胞介素6（sIL-6）在预测经导管动脉栓塞术（TAE）后治疗效果及不良反应方面的价值，对18例患者（3例仅行血管造影术，15例因肝细胞癌行TAE）在血管造影术或TAE前后检测sIL-6。仅行血管造影术的3例患者sIL-6未升高，而15例肝细胞癌患者TAE后sIL-6显著升高。TAE部分缓解患者术后48 - 72小时的sIL-6水平高于无反应患者（P = 0.045），出现不良反应患者6 - 24小时的sIL-6水平高于无不良反应患者（P = 0.019）。TAE后48 - 72小时的sIL-6水平反映TAE疗效，而TAE后6 - 24小时的水平与不良反应严重程度相关。因此，sIL-6可能是预测TAE治疗效果及不良反应的有用指标。
