Khilnani N M, Winchester P A, Zanzonico P, Trost D W, Binkert B, Sos T A
Department of Radiology, The New York Hospital-Cornell Medical Center, NY 10021, USA.
J Vasc Interv Radiol. 1998 Sep-Oct;9(5):786-92. doi: 10.1016/s1051-0443(98)70393-8.
To compare the rates of thrombolysis produced by forced intrathrombic injections of saline versus urokinase, as well as automated versus manual injections of urokinase, with use of an in vitro model of a vascular occlusion.
The rates of thrombolysis produced by forced intrathrombic injections of saline and urokinase were compared in an in vitro radiometric model utilizing I-125-labeled thrombus. Similar experiments were performed to compare manual and automated injections of urokinase. The dissolution of the thrombus was quantitatively monitored with use of a scintillation detector. Averaged time activity data for each type of experiment were fit to exponential functions and half times of lysis calculated. The differences in the half times for the experiments being compared were evaluated for significance with use of the Student t test.
The half times of lysis produced by forced intrathrombic injections of urokinase were substantially and significantly shorter than those produced by forced saline injections. The half time of lysis produced by automated injections was not significantly different than that produced by manual injections.
Forced intrathrombic injections of urokinase produce faster and substantially more thrombolysis when compared with similarly administered saline. Also, for forced intrathrombic injections of lytic agents, an automated injector is an equivalent alternative to manual injections.
使用血管闭塞的体外模型，比较强制血栓内注射生理盐水与尿激酶产生的溶栓率，以及尿激酶自动注射与手动注射的溶栓率。
在利用I-125标记血栓的体外放射性模型中，比较强制血栓内注射生理盐水和尿激酶产生的溶栓率。进行类似实验以比较尿激酶的手动注射和自动注射。使用闪烁探测器定量监测血栓的溶解情况。将每种实验类型的平均时间活性数据拟合为指数函数，并计算溶解半衰期。使用学生t检验评估所比较实验的半衰期差异的显著性。
强制血栓内注射尿激酶产生的溶解半衰期明显短于强制注射生理盐水产生的半衰期。自动注射产生的溶解半衰期与手动注射产生的半衰期无显著差异。
与同样注射的生理盐水相比，强制血栓内注射尿激酶产生的溶栓速度更快，溶栓效果更显著。此外，对于强制血栓内注射溶栓剂，自动注射器是手动注射的等效替代方法。
