Froelich J J, Freymann C, Hoppe M, Thiel T, Wagner H J, Barth K H, Klose K J
Medizinisches Zentrum für Radiologie, Abteilung für Strahlendiagnostik, Klinikum der Philipps-Universität, Marburg, Germany.
Cardiovasc Intervent Radiol. 1996 Nov-Dec;19(6):423-7. doi: 10.1007/BF02577631.
Manual and automatic pulse-spray infusion techniques are compared in vitro to evaluate the efficacy of thrombolysis and the distribution of urokinase and saline solution within thrombus using a pulse-spray catheter.
A pulse-spray catheter was introduced into a human thrombus within a stenotic flow model. Automatic and manual pulsed infusion of urokinase and automatic pulsed infusion of saline solution were compared. To quantify the efficacy of thrombolysis, pressure gradients were recorded proximal and distal to the thrombus and during the course of infusion. Distribution of infused urokinase was assessed radiographically.
The fastest and most homogeneous dissolution of the thrombus was achieved with automatic pulsed infusion of urokinase, shown by decreasing transthrombotic pressure gradients (p < 0.001, Wilcoxon, matched pairs). Manual pulsed infusion of urokinase or saline solution resulted in inhomogeneous thrombus dissolution and delayed thrombolysis.
Application of automatic pulse-spray injectors seems beneficial for more effective and homogeneous intraarterial pulse-spray thrombolysis when compared with conventional manual pulsed technique.
在体外比较手动和自动脉冲喷射输注技术，以评估使用脉冲喷射导管进行溶栓的效果以及尿激酶和盐溶液在血栓内的分布情况。
将脉冲喷射导管插入狭窄血流模型中的人体血栓内。比较尿激酶的自动和手动脉冲输注以及盐溶液的自动脉冲输注。为了量化溶栓效果，在血栓近端和远端以及输注过程中记录压力梯度。通过影像学评估注入的尿激酶的分布。
尿激酶自动脉冲输注实现了血栓最快且最均匀的溶解，表现为跨血栓压力梯度降低（p < 0.001，Wilcoxon配对检验）。尿激酶或盐溶液的手动脉冲输注导致血栓溶解不均匀且溶栓延迟。
与传统手动脉冲技术相比，应用自动脉冲喷射注射器似乎有利于更有效且均匀地进行动脉内脉冲喷射溶栓。
