血管舒张药物哌唑嗪和二氮嗪对犬血浆肾素活性的不同影响。

Differing effects of the vasodilator drugs, prazosin and diazoxide on plasma renin activity in the dog.

Graham R M, Muir M R, Hayes J M

Clin Exp Pharmacol Physiol. 1976 Mar-Apr;3(2):173-7. doi: 10.1111/j.1440-1681.1976.tb00602.x.

Abstract

The effects of intravenous (i.v.) administration of the vasodilator drugs prazosin or diazoxide on blood pressure and plasma renin activity were evaluated in the anaesthetized dog. 2. Prazosin and diazoxide both induced a rapid reduction in the mean arterial pressure to 73% and 75% of control values respectively. 3. Prazosin lowered plasma renin activity to 62% (P less than 0-025) of the control value whereas diazoxide raised plasma renin activity to 178% (P less than 0.05) of the control value. 4. The combination of vasodilatation and low renin activity observed following the administration of prazosin is unique, and may have clinical significance if these factors reduce the vascular complications of hypertension.

摘要

在麻醉犬中评估了静脉注射血管扩张剂哌唑嗪或二氮嗪对血压和血浆肾素活性的影响。2. 哌唑嗪和二氮嗪均使平均动脉压迅速降低，分别降至对照值的73%和75%。3. 哌唑嗪使血浆肾素活性降至对照值的62%（P<0.025），而二氮嗪使血浆肾素活性升至对照值的178%（P<0.05）。4. 哌唑嗪给药后观察到的血管扩张和低肾素活性的组合是独特的，如果这些因素减少高血压的血管并发症，可能具有临床意义。