哌唑嗪不会改变犬类因系统性低血压或肾内输注异丙肾上腺素和前列腺素I2而引起的肾素释放。
Prazosin does not alter canine renin release in response to systemic hypotension or intrarenal isoprenaline and prostaglandin I2 infusion.
作者信息
Gerber J G, Nies A S, Olson R D
出版信息
Br J Pharmacol. 1980;71(2):533-7. doi: 10.1111/j.1476-5381.1980.tb10969.x.
Abstract
- The effect of a hypotensive dose of intravenous prazosin (0.2 mg/kg) on heart rate and plasma renin activity was evaluated in anaesthetized mongrel dogs pretreated with indomethacin. 2. The effect of prazosin on the renin release elicited by the beta-adrenoceptor agonist isoprenaline and by prostaglandin I2 was also evaluated. 3. Prazosin administration was associated with a significant increase in heart rate and increase in plasma renin activity. 4. Prazosin did not interfere with the increase in plasma renin activity in response to either isoprenaline or prostaglandin I2. 5. We conclude that prazosin is not a unique peripheral vasodilator since hypotensive doses are associated with an increase in heart rate and plasma renin activity. In addition, prazosin does not inhibit the release of renin induced by either isoprenaline or prostaglandin I2.
摘要
- 在预先用吲哚美辛处理的麻醉杂种犬中，评估了静脉注射降压剂量的哌唑嗪（0.2毫克/千克）对心率和血浆肾素活性的影响。2. 还评估了哌唑嗪对β-肾上腺素能受体激动剂异丙肾上腺素和前列腺素I2引起的肾素释放的影响。3. 给予哌唑嗪后，心率显著增加，血浆肾素活性升高。4. 哌唑嗪不干扰对异丙肾上腺素或前列腺素I2反应时血浆肾素活性的增加。5. 我们得出结论，哌唑嗪不是一种独特的外周血管扩张剂，因为降压剂量会导致心率和血浆肾素活性增加。此外，哌唑嗪不抑制异丙肾上腺素或前列腺素I2诱导的肾素释放。
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Effect of diazoxide on plasma renin activity in hypertensive patients.二氮嗪对高血压患者血浆肾素活性的影响。
Ann Intern Med. 1967 Oct;67(4):791-9. doi: 10.7326/0003-4819-67-4-791.
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Renin release during acute reduction of arterial pressure in normotensive subjects and patients with renovascular hypertension.血压正常者和肾血管性高血压患者在动脉压急性降低期间的肾素释放。
J Clin Invest. 1967 May;46(5):705-16. doi: 10.1172/JCI105571.
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Adrenergic component of renin release induced by vasodilating antihypertensive drugs in the rat.血管舒张性抗高血压药物诱导大鼠肾素释放中的肾上腺素能成分
Circ Res. 1973 Jul;33(1):82-6. doi: 10.1161/01.res.33.1.82.
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Cardiovascular effects of prazosin in normotensive and genetically hypertensive rats.哌唑嗪对正常血压和遗传性高血压大鼠的心血管效应。
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