组胺对离体大鼠心脏作用的研究。

A study of the actions of histamine on the isolated rat heart.

Dai S

Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):359-67. doi: 10.1111/j.1440-1681.1976.tb00612.x.

Abstract

The effects of histamine on cardiac force, heart rate and coronary perfusion pressure were studied in the isolated rat heart, using the Langendorff perfused heart preparation. 2. Single injections of histamine induced dose-dependent decreases in contractile amplitude, heart rate and coronary perfusion pressure. 3. Perfusions of metiamide (above 1 x 10(-4) m) had a depressant effect on contractile force and heart rate, whereas diphenhydramine (4 x 10(-6) m) reduced only the heart rate. Both agents caused a fall in coronary perfusion pressure. 4. The negative inotropic and chronotropic effects of histamine on the isolated rat heart were not significantly influenced by either metiamide of diphenhydramine, or a combination of these drugs. However, the fall in coronary perfusion pressure induced by injections of histamine was significantly antagonized by metiamide or diphenhydramine. 5. These results suggest that the effects of histamine on the isolated rat heart may not be due entirely to stimulation of H1- or H2-receptors on the cardiac muscle cells. Evidence is presented for the existence of histamine H1- and H2-receptors in the coronary vessels.

摘要

使用Langendorff灌流心脏标本，在离体大鼠心脏中研究了组胺对心肌力、心率和冠状动脉灌注压的影响。2. 单次注射组胺可引起收缩幅度、心率和冠状动脉灌注压呈剂量依赖性下降。3. 甲硫咪特灌注（高于1×10⁻⁴ m）对收缩力和心率有抑制作用，而苯海拉明（4×10⁻⁶ m）仅降低心率。两种药物均导致冠状动脉灌注压下降。4. 组胺对离体大鼠心脏的负性肌力和变时作用不受甲硫咪特或苯海拉明单独或联合用药的显著影响。然而，注射组胺引起的冠状动脉灌注压下降被甲硫咪特或苯海拉明显著拮抗。5. 这些结果表明，组胺对离体大鼠心脏的作用可能并非完全归因于对心肌细胞上H1或H2受体的刺激。有证据表明冠状动脉血管中存在组胺H1和H2受体。