小儿嗜铬细胞瘤患者循环中的多巴胺-β-羟化酶（DβH）和儿茶酚胺

Circulating dopamine-beta-hydroxylase (DbetaH) and catecholamines in a paediatric phaeochromocytoma.

Helle K B, Serck-Hanssen G, Sövik O, Gutteberg T J, Hansen J R, Ose L, Stöa K F

Clin Exp Pharmacol Physiol. 1976 Sep-Oct;3(5):487-91. doi: 10.1111/j.1440-1681.1976.tb00627.x.

Abstract

Circulating catecholamines and dopamine-beta-hydroxylase (DbetaH) have been studied in a child with bilateral phaeochromocytoma. 2. Venous catheterization showed a great increase in catecholamine efflux from the left adrenal vein while DbetaH activity in the latter was only slightly elevated. 3. Circulating catecholamines fluctated greatly while DbetaH activity decreased gradually during the removal of the tumours. 4. Post-operatively, circulating catecholamines declined to normal values while DbetaH activity returned to pre-operative levels. 5. It is concluded that these tumours released circulating catecholamines independent of an exocytotic secretion of DbetaH and that the circulating DbetaH reflected the activity of the sympathetic nervous system.

摘要

对一名患有双侧嗜铬细胞瘤的儿童进行了循环儿茶酚胺和多巴胺-β-羟化酶（DβH）的研究。2. 静脉插管显示左肾上腺静脉儿茶酚胺流出量大幅增加，而后者的DβH活性仅略有升高。3. 在肿瘤切除过程中，循环儿茶酚胺波动很大，而DβH活性逐渐下降。4. 术后，循环儿茶酚胺降至正常水平，而DβH活性恢复到术前水平。5. 得出的结论是，这些肿瘤释放循环儿茶酚胺，与DβH的胞吐分泌无关，且循环DβH反映了交感神经系统的活性。