Malluche H H, Ritz E, Lange H P, Schoeppe W
Clin Nephrol. 1976 Oct;6(4):440-7.
Bone histology (iliac crest biopsies; undecalcified sections; micromorphometry) was studied by repeated biopsies in 19 patients on maintenance hemodialysis. Sampling error was assessed by taking two biopsies at one time. After an initial biopsy, patients were dialyzed either against 3.6 mEq Ca/l dialyzate or 3.9 mEq Ca/l dialyzate for 9-16 months before a second biopsy was taken. Bone histology failed to normalize irrespective of the dialyzate Ca concentration. Surface density of endosteal fibrosis diminished in a considerable proportion of the patients (9/19). Volumetric density of osteoid fell in 5 and rose in 4 of the patients.
对19例维持性血液透析患者进行重复活检，研究骨组织学（髂嵴活检；不脱钙切片；显微形态测定）。通过一次性取两份活检样本评估抽样误差。首次活检后，在进行第二次活检前，患者分别使用钙浓度为3.6 mEq/L或3.9 mEq/L的透析液进行9至16个月的透析。无论透析液钙浓度如何，骨组织学均未恢复正常。相当一部分患者（9/19）骨内膜纤维化的表面密度降低。类骨质的体积密度在5例患者中下降，在4例患者中上升。
