Franken P, Malafosse A, Tafti M
Biochemistry and Neurophysiology Unit, Department of Psychiatry, University of Geneva, CH-1225 Geneva, Switzerland.
Am J Physiol. 1998 Oct;275(4):R1127-37. doi: 10.1152/ajpregu.1998.275.4.R1127.
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of the EEG in six inbred mice strains. Mean spectral EEG profiles (0-25 Hz) over 24 h were obtained for paradoxical sleep (PS), slow-wave sleep (SWS), and wakefulness. A highly significant genotype-specific variation was found for theta peak frequency during both PS and SWS, which strongly suggests the presence of a gene with a major effect. The strain distribution of theta peak frequency during exploratory behavior differed from that during sleep. In SWS, the relative contributions of delta (1-4 Hz) and sigma (11-15) power to the EEG varied with genotype and power in both frequency bands was negatively correlated. In addition, the EEG dynamics at state transitions were analyzed with a 4-s resolution. The onset of PS, but not that of wakefulness, was preceded by a pronounced peak in high-frequency (>11 Hz) power. These findings are discussed in terms of the neurophysiological mechanisms underlying rhythm generation and their control and modulation by the brain stem reticular-activating system.
通过对六个近交系小鼠的脑电图（EEG）进行定量分析，评估了自发节律性脑电图活动中的遗传变异。获取了24小时内异相睡眠（PS）、慢波睡眠（SWS）和清醒状态下的平均频谱脑电图图谱（0-25Hz）。在PS和SWS期间，θ波峰值频率存在高度显著的基因型特异性变异，这强烈表明存在一个具有主要效应的基因。探索行为期间θ波峰值频率的品系分布与睡眠期间不同。在SWS中，δ波（1-4Hz）和σ波（11-15Hz）功率对EEG的相对贡献随基因型而变化，且两个频段的功率呈负相关。此外，以4秒分辨率分析了状态转换时的EEG动态。PS的开始之前，高频（>11Hz）功率出现明显峰值，而清醒状态则不然。根据节律产生的神经生理机制及其受脑干网状激活系统的控制和调节，对这些发现进行了讨论。
