一种评估喹诺酮类药物致癫痫潜力的早期新方法。
A new approach for early assessment of the epileptogenic potential of quinolones.
作者信息
Delon A, Pariat C, Courtois P, Bouquet S, Couet W
机构信息
UPRES-EA 1223, Faculté de Médecine et Pharmacie, Poitiers, France.
出版信息
Antimicrob Agents Chemother. 1998 Oct;42(10):2756-8. doi: 10.1128/AAC.42.10.2756.
Abstract
The epileptogenic potential of pefloxacin and norfloxacin, two quinolone antibiotics, was investigated in vivo in three different animal species by measuring drug concentrations in cerebrospinal fluid (CSF), which is part of the biophase, at the onset of convulsions. Interestingly, the pefloxacin-to-norfloxacin concentration ratios in CSF were virtually constant across the species (7.0, 6.6, and 6.0 in mice, rats, and rabbits, respectively), suggesting that this approach could be used to predict the relative epileptogenic potential of quinolones in humans.
摘要
通过在惊厥发作时测量作为生物相一部分的脑脊液（CSF）中的药物浓度，在三种不同动物物种体内研究了两种喹诺酮类抗生素培氟沙星和诺氟沙星的致癫痫潜力。有趣的是，CSF中培氟沙星与诺氟沙星的浓度比在不同物种间几乎恒定（小鼠、大鼠和兔子分别为7.0、6.6和6.0），这表明该方法可用于预测喹诺酮类药物在人体内的相对致癫痫潜力。
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本文引用的文献
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