一种评估喹诺酮类药物致癫痫潜力的早期新方法。
A new approach for early assessment of the epileptogenic potential of quinolones.
作者信息
Delon A, Pariat C, Courtois P, Bouquet S, Couet W
机构信息
UPRES-EA 1223, Faculté de Médecine et Pharmacie, Poitiers, France.
出版信息
Antimicrob Agents Chemother. 1998 Oct;42(10):2756-8. doi: 10.1128/AAC.42.10.2756.
Abstract
The epileptogenic potential of pefloxacin and norfloxacin, two quinolone antibiotics, was investigated in vivo in three different animal species by measuring drug concentrations in cerebrospinal fluid (CSF), which is part of the biophase, at the onset of convulsions. Interestingly, the pefloxacin-to-norfloxacin concentration ratios in CSF were virtually constant across the species (7.0, 6.6, and 6.0 in mice, rats, and rabbits, respectively), suggesting that this approach could be used to predict the relative epileptogenic potential of quinolones in humans.
摘要
通过在惊厥发作时测量作为生物相一部分的脑脊液（CSF）中的药物浓度，在三种不同动物物种体内研究了两种喹诺酮类抗生素培氟沙星和诺氟沙星的致癫痫潜力。有趣的是，CSF中培氟沙星与诺氟沙星的浓度比在不同物种间几乎恒定（小鼠、大鼠和兔子分别为7.0、6.6和6.0），这表明该方法可用于预测喹诺酮类药物在人体内的相对致癫痫潜力。
相似文献
1
A new approach for early assessment of the epileptogenic potential of quinolones.一种评估喹诺酮类药物致癫痫潜力的早期新方法。
Antimicrob Agents Chemother. 1998 Oct;42(10):2756-8. doi: 10.1128/AAC.42.10.2756.
2
Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.
J Pharmacol Exp Ther. 1997 Feb;280(2):983-7.
3
Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats.
Pharm Res. 1999 Dec;16(12):1894-7. doi: 10.1023/a:1011967813140.
4
Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats.将等效线图法扩展用于研究两种以上药物之间的相互作用：以培氟沙星、诺氟沙星与茶碱在大鼠体内的惊厥性相互作用为例
J Pharm Sci. 2004 Mar;93(3):553-62. doi: 10.1002/jps.10574.
5
Interaction between pefloxacin and aminophylline in genetically epilepsy-prone rats.培氟沙星与氨茶碱在遗传性癫痫易感性大鼠中的相互作用。
J Pharm Pharmacol. 1997 Oct;49(10):1025-9. doi: 10.1111/j.2042-7158.1997.tb06035.x.
6
Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.一种用于定量评估培氟沙星与茶碱在大鼠中惊厥相互作用的等效应线图新方法的开发。
Pharm Res. 1998 Jul;15(7):1069-76. doi: 10.1023/a:1011938429379.
7
Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats.
J Pharmacol Exp Ther. 1992 Dec;263(3):1140-6.
8
Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation.
Pharm Res. 1996 Jul;13(7):1065-8. doi: 10.1023/a:1016014909431.
9
In vitro antibacterial activity of three new quinolone derivatives: rosoxacin, norfloxacin, pefloxacin.三种新型喹诺酮衍生物：咯索沙星、诺氟沙星、培氟沙星的体外抗菌活性
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Dec;258(2-3):283-6. doi: 10.1016/s0176-6724(84)80046-2.
10
Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats.培氟沙星、诺氟沙星、氧氟沙星和环丙沙星的口服毒性：对大鼠跟腱生物力学和组织病理学影响的比较。
J Toxicol Sci. 2011 Jun;36(3):339-45. doi: 10.2131/jts.36.339.
引用本文的文献
1
Development of a physiologically-based pharmacokinetic model of the rat central nervous system.大鼠中枢神经系统生理基于模型的药代动力学模型的开发。
Pharmaceutics. 2014 Mar 18;6(1):97-136. doi: 10.3390/pharmaceutics6010097.
2
Ciprofloxacin-associated choreoathetosis in a haemodialysis patient.一名血液透析患者出现环丙沙星相关的舞蹈手足徐动症。
BMJ Case Rep. 2013 Apr 18;2013:bcr2013009293. doi: 10.1136/bcr-2013-009293.
3
Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats.在清醒大鼠中，无论有无联苯乙酸存在，惊厥剂量和亚惊厥剂量的诺氟沙星均会改变细胞外海马谷氨酸水平，但不会改变γ-氨基丁酸水平。
Antimicrob Agents Chemother. 2002 Feb;46(2):471-7. doi: 10.1128/AAC.46.2.471-477.2002.
4
Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats.
Pharm Res. 1999 Dec;16(12):1894-7. doi: 10.1023/a:1011967813140.
5
Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats.药代动力学-药效学对氟喹诺酮类药物在大鼠体内惊厥活性的影响。
Antimicrob Agents Chemother. 1999 Jun;43(6):1511-5. doi: 10.1128/AAC.43.6.1511.
6
Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.一种用于定量评估培氟沙星与茶碱在大鼠中惊厥相互作用的等效应线图新方法的开发。
Pharm Res. 1998 Jul;15(7):1069-76. doi: 10.1023/a:1011938429379.
本文引用的文献
1
Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.一种用于定量评估培氟沙星与茶碱在大鼠中惊厥相互作用的等效应线图新方法的开发。
Pharm Res. 1998 Jul;15(7):1069-76. doi: 10.1023/a:1011938429379.
2
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo.
Toxicol Appl Pharmacol. 1997 Aug;145(2):246-54. doi: 10.1006/taap.1997.8137.
3
Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.
J Pharmacol Exp Ther. 1997 Feb;280(2):983-7.
4
In vitro modulation of hippocampal pyramidal cell response by quinolones: effects of HA 966 and gamma-hydroxybutyric acid.
Antimicrob Agents Chemother. 1996 Nov;40(11):2573-6. doi: 10.1128/AAC.40.11.2573.
5
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
J Pharmacol Exp Ther. 1993 Feb;264(2):859-62.
6
Structure-activity and structure-side-effect relationships for the quinolone antibacterials.喹诺酮类抗菌药物的构效关系和构效副作用关系。
J Antimicrob Chemother. 1994 Apr;33(4):685-706. doi: 10.1093/jac/33.4.685.
7
8
9
Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats.
J Pharmacol Exp Ther. 1987 Apr;241(1):236-8.
10
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.
J Pharmacol Exp Ther. 1986 Mar;236(3):708-13.
Zotero 插件