El-Kabbani O, Wilson D K, Petrash M, Quiocho F A
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia.
Mol Vis. 1998 Sep 29;4:19.
The three-dimensional structures of aldose reductase and aldehyde reductase, members of the aldo-keto reductase superfamily, are composed of similar alpha/beta TIM-barrels. However, examination of the structures reveals that the inhibitor-binding site of aldose reductase differs from that of aldehyde reductase due to the participation of non-conserved residues in its formation. This information will be useful in the design of inhibitors to prevent or delay diabetic retinopathy. A review of the structures of the inhibitor-binding sites is presented.
醛糖还原酶和醛还原酶属于醛酮还原酶超家族，它们的三维结构由相似的α/β桶状结构组成。然而，对这些结构的研究表明，醛糖还原酶的抑制剂结合位点与醛还原酶的不同，这是由于非保守残基参与了其形成过程。这些信息将有助于设计预防或延缓糖尿病视网膜病变的抑制剂。本文对抑制剂结合位点的结构进行了综述。
