Borgå O, Cederlöf I O, Ringberger V A, Norlin A
Clin Pharmacol Ther. 1976 Oct;20(4):464-75. doi: 10.1002/cpt1976204464.
Protein binding of salicylate was studied by equilibrium dialysis at 37 degrees C in plasma from uremic patients and healthy subjects. The protein binding was considerably lower in the uremic plasma at all salicylate concentrations studied (14 to 1,400 mug/ml). Scatchard plots of the data were computer-analyzed assuming binding to the classes of binding sites. According to this analysis, the binding to the class of primary binding sites was considerably decreased in the uremic plasma. In addition to the effect of the uremic state, the binding was considerably decreased at high therapeutic plasma levels and at low albumin levels. The combined effect of two or three of these factors may lead to unexpectedly high unbound fractions of salicylate, which should be considered in the monitoring of plasma salicylate levels in patients.
在37摄氏度下，采用平衡透析法研究了尿毒症患者和健康受试者血浆中水杨酸盐的蛋白结合情况。在所研究的所有水杨酸盐浓度（14至1400微克/毫升）下，尿毒症血浆中的蛋白结合率均显著降低。假设与不同类别的结合位点结合，对数据进行Scatchard作图并通过计算机分析。根据该分析，尿毒症血浆中与主要结合位点类别的结合显著减少。除了尿毒症状态的影响外，在高治疗血浆水平和低白蛋白水平下，结合也显著降低。这些因素中的两个或三个因素共同作用可能导致水杨酸盐的游离分数意外升高，这在监测患者血浆水杨酸盐水平时应予以考虑。
