Tsudo M, Moriguchi T
Division of Hematology, Internal Medicine, Kyoto Katsura Hospital.
Gan To Kagaku Ryoho. 1998 Sep;25(11):1747-53.
We investigated the efficacy and safety of two methods of granisetron injection to treat nausea and vomiting induced by chemotherapy for tumors in hematopoietic organs. The methods of administration were intravenous drip infusion over 30 minutes, which is the conventional method, and intravenous bolus injection. In this study, 89.5% of patients in both groups (17/19 for each) were free from vomiting. No serious adverse events were observed in either administration group. Abnormal laboratory test values suspected to be related to granisetron were observed in 3 cases in the bolus injection group and in 2 cases in the drip infusion group. but did not pose any clinical problem. These results demonstrated the safety of both methods of administration. In conclusion, it is considered that granisetron intravenous bolus injection can be considered as the method of choice for the prevention of nausea and vomiting induced by chemotherapy for tumors in hematopoietic organs.
我们研究了两种格拉司琼注射方法治疗造血器官肿瘤化疗所致恶心和呕吐的疗效及安全性。给药方法分别为常规的30分钟静脉滴注法和静脉推注法。本研究中，两组患者（每组19例）均有89.5%未出现呕吐。两个给药组均未观察到严重不良事件。静脉推注组有3例、静脉滴注组有2例出现怀疑与格拉司琼相关的实验室检查值异常，但未引发任何临床问题。这些结果证明了两种给药方法的安全性。总之，认为格拉司琼静脉推注可作为预防造血器官肿瘤化疗所致恶心和呕吐的首选方法。
