James S H, Schnoll S H
Clin Toxicol. 1976;9(4):573-82. doi: 10.3109/15563657608988159.
This study was performed to provide knowledge of the tissue distribution of phencyclidine and has demonstrated the lipophilic nature of the drug. The distribution of phencyclidine in blood, brain, and adipose tissue of rats has been determined at various time intervals during a 48-hr period. The affinity of phencyclidine for adipose tissue and the demonstration of the presence of this drug in brain tissue long after it is no longer detectable in blood provides some correlation between the tissue distribution of phencyclidine and its clinical manifestations occuring 24-48 hr after administration.
进行这项研究是为了了解苯环己哌啶的组织分布情况，并已证明该药物具有亲脂性。在48小时内的不同时间间隔测定了苯环己哌啶在大鼠血液、大脑和脂肪组织中的分布。苯环己哌啶对脂肪组织的亲和力以及在血液中不再可检测到该药物很长时间后在脑组织中仍能证明其存在，这为苯环己哌啶的组织分布与其给药后24 - 48小时出现的临床表现之间提供了一些关联。
