Chari-Bitron A, Simon G A, Kadar T, Motola L
Arch Toxicol. 1979 Dec;43(2):85-92. doi: 10.1007/BF00333614.
The present whole-body autoradiographic study demonstrates that the circulatory system is practically free of radioactivity, already 5 min after intravenous administration of 3H-Phencyclidine to mice. At this time, however, high radioactive levels appear in the lachrymal gland, nasal mucosa, bone marrow and spleen, as well as in the urinary, digestive, respiratory and reproductive systems. High accumulation is maintained up to 20 min after administration and, thereafter, radioactivity declines continuously with increasing time. After 6 h, radioactivity disappears in most organs, but remains notable in the kidney, lung and liver, as well as in the salivary and lachrymal glands. After 24 h, detectable amounts still persist in the liver, lung and in the salivary and lachrymal glands. The brain shows very low amounts of radioactivity during the whole period of observation. In pregnant mice, the drug accumulates in the placenta and partly crosses the placental barrier into the foetal tissues.
目前的全身放射自显影研究表明，给小鼠静脉注射3H-苯环己哌啶5分钟后，循环系统实际上已无放射性。然而，此时泪腺、鼻粘膜、骨髓和脾脏以及泌尿、消化、呼吸和生殖系统中出现高放射性水平。给药后20分钟内保持高积累，此后，放射性随时间增加而持续下降。6小时后，大多数器官中的放射性消失，但肾脏、肺和肝脏以及唾液腺和泪腺中仍有明显放射性。24小时后，肝脏、肺以及唾液腺和泪腺中仍存在可检测到的量。在整个观察期内，大脑中的放射性含量非常低。在怀孕小鼠中，药物积聚在胎盘中，并部分穿过胎盘屏障进入胎儿组织。
