Ahmed S S, Regan T J
Compr Ther. 1976 Nov;2(11):51-7.
Chronic diabetes mellitus can alter left ventricular function independent of vascular effects. On the basis of available morphologic data in human and canine diabetics, alterations of myocardial interstitium may be the basis for this preclinical abnormality. The abnormal function is independent of apparent duration and treatment by diet, insulin, or hypoglycemic agents. It occurs in both sexes and is independent of age. Whether the observed functional abnormality progresses to clinical heart failure may depend on intensification of the underlying pathophysiology of the myocardium or superimposition of complications such as hypertension, obesity, and obstructive disease of the coronary vessels.
慢性糖尿病可独立于血管效应而改变左心室功能。根据人类和犬类糖尿病患者现有的形态学数据，心肌间质的改变可能是这种临床前异常的基础。这种异常功能与明显的病程以及饮食、胰岛素或降糖药物治疗无关。它在男女中均有发生，且与年龄无关。观察到的功能异常是否会发展为临床心力衰竭可能取决于心肌潜在病理生理学的强化或高血压、肥胖和冠状动脉阻塞性疾病等并发症的叠加。
