Denys A
Zakładu Mikrobiologii Lekarskiej WAM w Lodzi.
Otolaryngol Pol. 1997;51 Suppl 25:171-4.
Generation of strains resistant to antibiotics, its genetic mechanisms and the role of incompetent administration of these drugs are presented in the paper. The resistance is characterised mainly by the generation of extracellular enzymes which cause the breakdown of beta-lactam ring Pathogenic bacteria which cause changes in the respiratory system are discussed. The use of beta-lactam antibiotics with beta-lactam inhibitors is a way to prevent generation of resistant strains, the combination of amoxycillin and clavulanic acid is of particular importance.
本文介绍了抗生素耐药菌株的产生、其遗传机制以及这些药物管理不当所起的作用。耐药性主要表现为产生可导致β-内酰胺环断裂的细胞外酶。文中讨论了引起呼吸系统变化的病原菌。使用β-内酰胺类抗生素与β-内酰胺酶抑制剂的联合用药是预防耐药菌株产生的一种方法，阿莫西林与克拉维酸的组合尤为重要。
