黑猩猩和恒河猴群体中Mhc - DPB1等位基因的特征与分布
Characterization and distribution of Mhc-DPB1 alleles in chimpanzee and rhesus macaque populations.
作者信息
Otting N, Doxiadis G G, Versluis L, de Groot N G, Anholts J, Verduin W, Rozemuller E, Claas F, Tilanus M G, Bontrop R E
机构信息
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
出版信息
Hum Immunol. 1998 Oct;59(10):656-64. doi: 10.1016/s0198-8859(98)00070-6.
Allelic diversity at the nonhuman primate Mhc-DPB1 locus was studied by determining exon 2 nucleotide sequences. This resulted in the detection of 17 chimpanzee (Pan troglodytes), 2 orangutan (Pongo pygmaeus) and 16 rhesus macaque (Macaca mulatta) alleles. These were compiled with primate Mhc-DPB1 nucleotide sequences that were published previously. Based upon the results, a sequence specific oligotyping method was developed allowing us to investigate the distribution of Mhc-DPB1 alleles in distinct chimpanzee and rhesus macaque colonies. Like found in humans, chimpanzee and rhesus macaque populations originating from different geographic backgrounds appear to be characterized by the presence of a few dominant Mhc-DPB1 alleles.
通过测定外显子2核苷酸序列，研究了非人灵长类动物Mhc - DPB1基因座的等位基因多样性。这导致检测到17个黑猩猩（Pan troglodytes）、2个猩猩（Pongo pygmaeus）和16个恒河猴（Macaca mulatta）等位基因。这些等位基因与先前发表的灵长类Mhc - DPB1核苷酸序列汇编在一起。基于这些结果，开发了一种序列特异性寡核苷酸分型方法，使我们能够研究Mhc - DPB1等位基因在不同黑猩猩和恒河猴群体中的分布。与人类一样，来自不同地理背景的黑猩猩和恒河猴群体似乎也以存在少数优势Mhc - DPB1等位基因为特征。
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