Seibert KD, Burns MA
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2136, USA.
Biotechnol Prog. 1998 Sep;14(5):749-55. doi: 10.1021/bp980080z.
Direct fermentation broth processing using fluidized beds is extremely advantageous due to the low operating pressure drop of the device and the ability of the bed to process suspended-solids-containing solutions. Unfortunately, the solid particles in fluidized beds typically show a great deal of mixing compared to those in packed beds. This mixing may lead to early breakthrough and inefficient use of adsorptive capacity. Stabilization reduces the solids mixing and improves the performance and efficiency of a fluidized bed. A comparison of packed, fluidized, and stabilized beds reveals that, while normal fluidized beds do contain a significant amount of mixing, the breakthrough behavior of the bed is not drastically different than that of a packed bed. Magnetic stabilization of the bed usually leads to an increase in adsorption efficiency but is dependent on field strength and orientation. Permanently magnetized beds were also investigated and produced breakthrough efficiencies similar to those of packed beds.
使用流化床直接处理发酵液极具优势,这是因为该装置的操作压降较低,且流化床能够处理含悬浮固体的溶液。不幸的是,与填充床中的固体颗粒相比,流化床中的固体颗粒通常表现出大量的混合。这种混合可能导致过早穿透以及吸附容量的低效利用。稳定化可减少固体混合,并提高流化床的性能和效率。对填充床、流化床和稳定化床的比较表明,虽然普通流化床确实存在大量混合,但该床的穿透行为与填充床相比并无显著差异。床层的磁稳定通常会提高吸附效率,但这取决于场强和方向。还对流化床永久磁化进行了研究,其产生的穿透效率与填充床相似。