Gilboa-Garber N, Kirstein-Segal R
Department of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel.
Mol Genet Metab. 1998 Aug;64(4):283-5. doi: 10.1006/mgme.1998.2703.
Serotonin, a neurotransmitter and vasoconstrictor, affects various cell properties. We have analyzed the importance of its structural components for its extensive effect on human erythrocyte fragility, using its O- and N-linked derivatives and related compounds. The results presented in this communication indicate that the amino group, free of adjacent negative charges, and the hydroxyl group are indispensable for the serotonin-induced increase in red blood cell fragility.
血清素是一种神经递质和血管收缩剂，会影响多种细胞特性。我们利用其O-连接和N-连接衍生物及相关化合物，分析了其结构成分对人类红细胞脆性产生广泛影响的重要性。本通讯中呈现的结果表明，没有相邻负电荷的氨基和羟基对于血清素诱导的红细胞脆性增加是不可或缺的。
