Kozubek A
Institute of Biochemistry, University of Wrocław, Poland.
Acta Biochim Pol. 1987;34(4):357-67.
The influence of 5-(n-heptadecenyl)resorcinol, one of the main rye grain resorcinol derivatives, on the erythrocyte membrane permeability for nonelectrolytes differing in molecular size was studied turbidimetrically at various concentrations of the resorcinol derivative studied. The alkenylresorcinol induced increased permeability of the erythrocyte membrane for all the solutes studied (glycerol, m-erythritol, D-glucose, sucrose and polyethylene glycol 1000). At a given concentration of 5-(n-heptadecenyl)resorcinol the highest permeability increases were obtained for the smallest solutes. The membrane lipid to alkenylresorcinol ratio necessary for initiation of the increase of the erythrocyte membrane permeability for the solutes studied varied from 273 to 82 for glycerol and polyethylene glycol 1000, respectively, indicating that this strong membrane perturbing action may be primarily responsible for the biological effect of phenolic lipids.
研究了黑麦谷物中主要间苯二酚衍生物之一的5-（正十七碳烯基）间苯二酚，在不同浓度下对不同分子大小的非电解质红细胞膜通透性的影响，采用比浊法进行研究。烯基间苯二酚使所研究的所有溶质（甘油、间赤藓糖醇、D-葡萄糖、蔗糖和聚乙二醇1000）的红细胞膜通透性增加。在给定浓度的5-（正十七碳烯基）间苯二酚下，最小的溶质获得的通透性增加最高。对于所研究的溶质，引发红细胞膜通透性增加所需的膜脂与烯基间苯二酚的比例分别从甘油的273到聚乙二醇1000的82不等，这表明这种强烈的膜扰动作用可能是酚类脂质生物学效应的主要原因。
