Schimmel T G, Coffman A D, Parsons S J
Technical Operations, Merck and Co., Inc., Elkton, Virginia 22827, USA.
Appl Environ Microbiol. 1998 Oct;64(10):3707-12. doi: 10.1128/AEM.64.10.3707-3712.1998.
Butyrolactone I [alpha-oxo-beta-(p-hydroxyphenyl)-gamma-(p-hydroxy-m-3, 3-dimethylallyl-benzyl)-gamma-methoxycarbonyl-gamma-butyrolactone] is produced as a secondary metabolite by Aspergillus terreus. Because small butyrolactone-containing molecules act as self-regulating factors in some bacteria, the effects of butyrolactone I on the producing organism were studied; specifically, changes in morphology, sporulation, and secondary metabolism were studied. Threefold or greater increases in hyphal branching (with concomitant decreases in the average hyphal growth unit), submerged sporulation, and secondary metabolism were observed when butyrolactone I was added to cultures of A. terreus. Among the secondary metabolites whose production was increased by this treatment was the therapeutically important compound lovastatin. These findings indicate that butyrolactone I induces morphological and sporulation changes in A. terreus and enhances secondary metabolite production in a manner similar to that previously reported for filamentous bacteria.
丁内酯I [α-氧代-β-(对羟基苯基)-γ-(对羟基间-3, 3-二甲基烯丙基苄基)-γ-甲氧基羰基-γ-丁内酯] 是土曲霉产生的一种次级代谢产物。由于含丁内酯的小分子在某些细菌中作为自我调节因子，因此研究了丁内酯I对产生该物质的生物体的影响；具体而言，研究了形态、孢子形成和次级代谢的变化。当将丁内酯I添加到土曲霉培养物中时，观察到菌丝分支增加了三倍或更多（同时平均菌丝生长单位减少）、深层孢子形成和次级代谢增加。通过这种处理产量增加的次级代谢产物中包括具有治疗重要性的化合物洛伐他汀。这些发现表明，丁内酯I诱导土曲霉的形态和孢子形成变化，并以与先前报道的丝状细菌类似的方式增强次级代谢产物的产生。
