Huang Y, Watanabe N, Ohtomo H
Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan.
Int Arch Allergy Immunol. 1998 Sep;117 Suppl 1:2-4. doi: 10.1159/000053561.
The costimulatory signal provided by the interaction between CD28 and its ligands, CD80 and CD86, is critical for T cell activation. The requirement of CD80 and CD86 in T cell activation for eosinophilia and IgE production was examined in mice infected with the nematode parasite Nippostrongylus brasiliensis. Combined treatment with anti-CD80 and anti-CD86 suppressed eosinophilia in the blood and the small intestine and suppressed IgE production. However, administration of either anti-CD80 or anti-CD86 alone had little effect on eosinophilia and on the elevation of IgE levels. These results suggest that CD80 and CD86 costimulation is required and either CD80 or CD86 can provide a sufficient costimulatory signal for induction of eosinophilia in mice infected with N. brasiliensis.
CD28与其配体CD80和CD86相互作用所提供的共刺激信号对于T细胞活化至关重要。在感染巴西日圆线虫这种线虫寄生虫的小鼠中，研究了CD80和CD86在T细胞活化以引发嗜酸性粒细胞增多和产生IgE方面的需求。抗CD80和抗CD86联合治疗可抑制血液和小肠中的嗜酸性粒细胞增多，并抑制IgE产生。然而，单独给予抗CD80或抗CD86对嗜酸性粒细胞增多和IgE水平升高几乎没有影响。这些结果表明，CD80和CD86共刺激是必需的，并且CD80或CD86中的任何一种都可为感染巴西日圆线虫的小鼠诱导嗜酸性粒细胞增多提供足够的共刺激信号。
