Terezhalmy G T, Bergfeld W F
Department of Dentistry, Cleveland Clinic Foundation, Ohio 44195, USA.
Quintessence Int. 1998 Jul;29(7):429-37.
Cicatricial pemphigoid is a chronic mucocutaneous bullous condition. It is a heterogenous autoimmune disease, characterized by the production of autoantibodies against basement membrane zone antigens. The target antigens in cicatricial pemphigoid appear to be lamina lucida proteins involved in human keratinocyte adhesion to extracellular matrix. Cicatricial pemphigoid primarily affects persons older than 40 years and appears to have a 2:1 predilection for women, without racial or geographic bias.
瘢痕性类天疱疮是一种慢性黏膜皮肤大疱性疾病。它是一种异质性自身免疫性疾病，其特征是产生针对基底膜区抗原的自身抗体。瘢痕性类天疱疮的靶抗原似乎是参与人类角质形成细胞与细胞外基质黏附的透明层蛋白。瘢痕性类天疱疮主要影响40岁以上的人群，且女性发病率似乎是男性的两倍，无种族或地域倾向。
