Bozkurt F Y, Celenligil H, Sungur A, Ruacan S
Department of Periodontology, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey.
Quintessence Int. 1998 Jul;29(7):438-41.
A 60-year-old woman with clinical features of desquamative gingivitis had a history of painful, blistering gingival lesions for more than 2 years. There were no other accompanying mucosal or skin lesions. Clinical examination revealed erythematous and edematous gingiva with ulcerated areas and evidence of intact and ruptured bullae. White plaquelike lesions were also noted. Gingival manipulation caused epithelial desquamation. Light microscopic examination of biopsy specimens from the perilesional gingival tissue showed separation of the oral gingival epithelium and connective tissue at the margin of the collapsed bulla. A moderately intense inflammatory infiltrate was present in the connective tissue. Direct immunofluorescent microscopy revealed a continuous linear deposition of immunoglobulin G and C3 at the basement membrane zone. On the basis of clinical, histopathologic, and immunofluorescent findings, the diagnosis of mucous membrane pemphigoid was made.
一名60岁女性，有剥脱性龈炎的临床特征，出现疼痛性水疱性牙龈病变超过2年。无其他伴发的黏膜或皮肤病变。临床检查发现牙龈红肿，有溃疡区域，可见完整和破裂的水疱。还注意到白色斑块样病变。牙龈触诊导致上皮剥脱。对病损周围牙龈组织活检标本进行光镜检查，显示在塌陷水疱边缘口腔牙龈上皮与结缔组织分离。结缔组织中有中度炎性浸润。直接免疫荧光显微镜检查显示免疫球蛋白G和C3在基底膜区呈连续线性沉积。根据临床、组织病理学和免疫荧光检查结果，诊断为黏膜类天疱疮。
