Shoenfeld Y, Sherer Y, Blank M
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
Scand J Rheumatol Suppl. 1998;107:33-6.
The antiphospholipid (APS) syndrome frequently includes severe pregnancy complications such as fetal wastage and recurrent spontaneous abortions. Animal models for APS in pregnancy can provide both an understanding of the pathogenic mechanisms of anti-phospholipid antibodies (aPL), and aid in the evaluation of various therapeutic modalities in APS. Animal models for APS include both spontaneously developed diseases, as is the case for secondary APS in mice with another autoimmune disease, and induced models of APS. The latter includes either passive induction of disease by antibodies infusion, or active induction via manipulation of the idiotypic network. This article summarizes the literature reports of animal models of APS in pregnancy, deal with the various possible mechanisms of action of aPL in pregnancy, and discuss the treatment options of women having pregnancy complications of APS.
抗磷脂综合征（APS）常伴有严重的妊娠并发症，如胎儿丢失和复发性自然流产。妊娠期APS动物模型有助于理解抗磷脂抗体（aPL）的致病机制，并有助于评估APS的各种治疗方式。APS动物模型包括自发产生的疾病，如患有另一种自身免疫性疾病的小鼠发生的继发性APS，以及诱导性APS模型。后者包括通过输注抗体被动诱导疾病，或通过操纵独特型网络主动诱导疾病。本文总结了妊娠期APS动物模型的文献报道，探讨了aPL在妊娠中的各种可能作用机制，并讨论了患有APS妊娠并发症女性的治疗选择。
