Comas D, Calafell F, Mateu E, Pérez-Lezaun A, Bertranpetit J
Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Spain.
Ann Hum Genet. 1998 Mar;62(Pt 2):123-32. doi: 10.1046/j.1469-1809.1998.6220123.x.
To examine the possible internal heterogeneity within the Basque population, nine samples typed for several HLA loci were compiled and HLA-A, B, C and DR loci were analysed. First, the shared features of HLA in Basques were analysed by principal component analysis and genetic distances. Two major Basque dialect groups ('French' and 'Spanish') were considered. FST statistics were computed and corrected for sampling intensity. The dialectal and political division did not seem to differentiate these two groups genetically. Analysis of Molecular Variance also failed to show consistently significant genetic variance components between French and Spanish Basques. Thus, in this particular example, linguistic diversity does not seem to correlate with a genetic stratification.
为了研究巴斯克人群中可能存在的内部异质性，我们收集了九个针对多个HLA位点进行分型的样本，并对HLA - A、B、C和DR位点进行了分析。首先，通过主成分分析和遗传距离分析了巴斯克人HLA的共同特征。考虑了两个主要的巴斯克方言群体（“法语”和“西班牙语”）。计算了FST统计量并对抽样强度进行了校正。方言和政治划分似乎并没有在基因上区分这两个群体。分子方差分析也未能显示出法国巴斯克人和西班牙巴斯克人之间始终存在显著的遗传方差成分。因此，在这个特定的例子中，语言多样性似乎与遗传分层没有关联。
