Massagué J
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Annu Rev Biochem. 1998;67:753-91. doi: 10.1146/annurev.biochem.67.1.753.
The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
转化生长因子β（TGF-β）家族生长因子控制后生动物大多数组织的发育和内环境稳定。过去几年的研究已阐明了一个TGF-β信号转导网络。该网络涉及细胞表面的受体丝氨酸/苏氨酸激酶及其底物SMAD蛋白，SMAD蛋白进入细胞核，在那里它们与DNA结合伴侣共同激活靶基因转录。受体、SMAD蛋白和DNA结合伴侣的不同组合似乎以细胞特异性方式构成了TGF-β及相关因子多功能性的基础。这些信号通路中的突变是多种人类癌症和发育障碍的病因。
