Aguayo Francisco, Tapia Julio C, Calaf Gloria M, Muñoz Juan P, Osorio Julio C, Guzmán-Venegas Matías, Moreno-León Carolina, Levican Jorge, Andrade-Madrigal Cristian
Laboratorio de Oncovirología, Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.
Laboratorio de Transformación Celular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile.
Int J Mol Sci. 2025 May 3;26(9):4354. doi: 10.3390/ijms26094354.
Xenobiotics are non-natural chemical compounds to which the human population is exposed. Chronic exposure to certain xenobiotics is associated with various diseases, including cancer development. Anelloviruses (AVs), including Torque Teno Virus (TTV), Torque Teno Mini Virus (TTMV), and Torque Teno Midi Virus (TTMDV), are ubiquitous viruses found in the general population. As no disease has been definitively associated with AVs, they are sometimes referred to as "viruses awaiting a disease". This review explores the potential roles of xenobiotics and AVs in colorectal cancer (CRC) development and suggests a potential interplay between them. Evidence suggests an association between certain xenobiotics (like pesticides, cigarette smoke components, and dietary factors) and CRC, while such an association is less clear for AVs. The high prevalence of AVs suggests these infections alone may be insufficient to disrupt homeostasis; thus, additional factors might be required to promote disease, potentially including cancer.
外源性物质是人类接触到的非天然化合物。长期接触某些外源性物质与包括癌症发展在内的各种疾病有关。环病毒（AVs），包括细小病毒B19、微小环病毒（TTMV）和中环病毒（TTMDV），是在普通人群中普遍存在的病毒。由于目前尚无明确与AVs相关的疾病，它们有时被称为“等待引发疾病的病毒”。本综述探讨了外源性物质和AVs在结直肠癌（CRC）发展中的潜在作用，并提出了它们之间可能存在的相互作用。有证据表明某些外源性物质（如农药、香烟烟雾成分和饮食因素）与CRC之间存在关联，而AVs与CRC的这种关联尚不太明确。AVs的高流行率表明，仅这些感染可能不足以破坏体内平衡；因此，可能需要其他因素来促进疾病，包括癌症。
