Letizia C, Boirivant M, De Toma G, Cerci S, Subioli S, Scuro L, Ferrari P, Pallone F
2nd Institute of Internal Medicine, Rome, Italy.
Ital J Gastroenterol Hepatol. 1998 Jun;30(3):266-9.
The purpose of this study was to investigate the behavior of circulating endothelin-1, a vasoconstrictor and mitogenic peptide, in patients with inflammatory bowel disease.
We investigated plasma endothelin-1 levels in 29 patients with Crohn's disease, 13 with ulcerative colitis and 26 healthy subjects as controls.
Erythrocyte sedimentation and C-reactive protein were also measured in all patients. Plasma endothelin-1 was measured by specific radioimmunoassay and expressed as pg/ml.
Both Crohn's disease and ulcerative colitis patients showed a significant increase in plasma endothelin-1 concentration (22.3 +/- 8.2 pg/ml and 11.2 +/- 2.7 pg/ml, respectively) when compared to healthy subjects (6.2 +/- 1.5 pg/ml). Moreover, plasma endothelin-1 levels were significantly higher in Crohn's disease patients than those in ulcerative colitis patients (22.3 +/- 8.2 pg/ml vs 11.2 +/- 2.7 pg/ml; p < 0.001, respectively). A weak correlation (r = 0.645; p < 0.013) between erythrocyte sedimentation and endothelin-1 levels was observed in Crohn's disease patients. Age, sex, clinical activity of the disease, duration of history, anatomical localization of disease and therapy had no influence on plasma endothelin-1 levels.
Our results show that plasma endothelin-1 levels increase in chronic inflammatory bowel disease and mainly in Crohn's disease. This observation leads us on to believe that endothelin-1 has a important role in inflammatory bowel disease.
本研究旨在调查炎症性肠病患者体内血管收缩剂和促有丝分裂肽——循环内皮素-1的表现。
我们调查了29例克罗恩病患者、13例溃疡性结肠炎患者以及26名健康受试者（作为对照）的血浆内皮素-1水平。
所有患者均检测了红细胞沉降率和C反应蛋白。血浆内皮素-1通过特异性放射免疫测定法进行检测，并以pg/ml表示。
与健康受试者（6.2±1.5 pg/ml）相比，克罗恩病患者和溃疡性结肠炎患者的血浆内皮素-1浓度均显著升高（分别为22.3±8.2 pg/ml和11.2±2.7 pg/ml）。此外，克罗恩病患者的血浆内皮素-1水平显著高于溃疡性结肠炎患者（22.3±8.2 pg/ml对11.2±2.7 pg/ml；p<0.001）。在克罗恩病患者中观察到红细胞沉降率与内皮素-1水平之间存在弱相关性（r = 0.645；p<0.013）。年龄、性别、疾病的临床活动度、病史时长、疾病的解剖定位和治疗对血浆内皮素-1水平均无影响。
我们的结果表明，慢性炎症性肠病患者，尤其是克罗恩病患者的血浆内皮素-1水平升高。这一观察结果使我们相信内皮素-1在炎症性肠病中起重要作用。
