López Morante A J, Sáez-Royuela F, Yuguero del Moral L, Martín Lorente J L, Ojeda Giménez C
Sección de Aparato Digestivo, Hospital General Yagüe, Burgos.
Rev Esp Enferm Dig. 1993 Jan;83(1):5-9.
Serum concentrations of C-Reactive protein (CRP) were measured in 40 patients with inflammatory bowel disease (22 with ulcerative colitis and 18 with Crohn's disease). In the evaluation of disease activity, CRP was a more sensitive (98.6% vs 71.4%) and specific (95% vs 84.6%) activity index in Crohn's disease than in ulcerative colitis. The CRP concentrations were significantly higher in Crohn's disease (57.7 +/- 55.7 mg/dl) than in ulcerative colitis (16.3 +/- 18.8 mg/dl), particularly in severely affected patients (104.8 +/- 54.3 vs 29 +/- 24.2 mg/dl). The CRP levels correlated significantly with clinical activity indices. There was poor or no correlation between CRP levels and the endoscopic activity indices, the extent of inflammatory bowel disease, and the days of hospitalization. We conclude that the determination of CRP levels provide a simple objective index of inflammatory activity with may be useful in the assessment, management and study of inflammatory bowel disease.
对40例炎症性肠病患者（22例溃疡性结肠炎患者和18例克罗恩病患者）测定了血清C反应蛋白（CRP）浓度。在评估疾病活动度时，与溃疡性结肠炎相比，CRP在克罗恩病中是一个更敏感（98.6%对71.4%）和特异（95%对84.6%）的活动指标。克罗恩病患者的CRP浓度（57.7±55.7mg/dl）显著高于溃疡性结肠炎患者（16.3±18.8mg/dl），尤其是在病情严重的患者中（104.8±54.3对29±24.2mg/dl）。CRP水平与临床活动指标显著相关。CRP水平与内镜活动指标、炎症性肠病的范围以及住院天数之间相关性较差或无相关性。我们得出结论，CRP水平的测定提供了一个简单的炎症活动客观指标，可能有助于炎症性肠病的评估、管理和研究。
