尼美舒利诱发的荨麻疹患者对阿司匹林和对乙酰氨基酚的耐受性
Aspirin and paracetamol tolerance in patients with nimesulide-induced urticaria.
作者信息
Asero R
机构信息
Ambulatorio di Allergologia, Ospedale Caduti Bollatesi, Bollate (MI), Italy.
出版信息
Ann Allergy Asthma Immunol. 1998 Sep;81(3):237-8. doi: 10.1016/S1081-1206(10)62818-9.
BACKGROUND
The administration of aspirin and other nonsteroidal anti-inflammatory drugs in patients sensitive to nimesulide might be hazardous.
OBJECTIVE
To assess the tolerance to both acetaminophen (paracetamol) and aspirin in patients with a history of urticaria induced by nimesulide.
METHODS
Nine patients with a history of nimesulide intolerance were submitted to single-blind, placebo-controlled peroral challenges with increasing doses of acetaminophen and aspirin.
RESULTS
Acetaminophen was tolerated by all patients, whereas two experienced immediate systemic urticaria after the administration of 125 mg of aspirin.
CONCLUSION
Acetaminophen and aspirin are well tolerated by most nimesulide-sensitive patients. Since a minority of patients show aspirin sensitivity, tolerance of this agent should always be ascertained by properly performed peroral challenges.
背景
在对尼美舒利敏感的患者中使用阿司匹林和其他非甾体抗炎药可能具有危险性。
目的
评估有尼美舒利诱发荨麻疹病史的患者对乙酰氨基酚（扑热息痛）和阿司匹林的耐受性。
方法
9例有尼美舒利不耐受病史的患者接受了递增剂量的乙酰氨基酚和阿司匹林的单盲、安慰剂对照口服激发试验。
结果
所有患者对乙酰氨基酚均耐受，而2例患者在服用125mg阿司匹林后立即出现全身性荨麻疹。
结论
大多数对尼美舒利敏感的患者对乙酰氨基酚和阿司匹林耐受性良好。由于少数患者表现出阿司匹林敏感性，因此应始终通过适当的口服激发试验来确定对该药物的耐受性。
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