Erel F, Karaayvaz M, Deveci M, Ozangüç N
Department of Allergy, Gülhane Military Medical Academy, Ankara, Turkey.
Ann Allergy Asthma Immunol. 1998 Sep;81(3):257-60. doi: 10.1016/S1081-1206(10)62822-0.
Anaphylaxis to topical application of rifamycin SV, which is used topically in the fields of surgery and dermatology, is rare.
We report two cases of systemic reactions occurring after local administration of rifamycin (Rifocine, Gruppo Lepetit, Italy). Both of them needed repeated intermittent topical applications. Skin prick tests with Rifocine constituents were performed on our patients, and also on ten atopic and ten nonatopic subjects. Although an old investigative tool, Prausnitz-Küstner (P-K) test was also performed on one of the patient's spouses to show passive transfer and the IgE-mediated mechanism.
Allergy assessment with skin tests on the patients were negative for aeroallergens, latex, and Rifocine constituents (except rifamycin SV). The patients' prick tests with rifamycin SV were positive, and the control subjects were negative. P-K testing was positive.
Two case reports support the existence of IgE-mediated reactions to rifamycin SV. IgE-mediated anaphylactic reactions from rifamycin SV appear to be extremely rare.
利福霉素SV常用于外科和皮肤科局部用药，对其局部应用发生过敏反应的情况较为罕见。
我们报告了两例局部应用利福霉素（Rifocine，意大利Gruppo Lepetit公司生产）后出现全身反应的病例。两名患者均需要反复间歇性局部用药。我们对这两名患者以及10名特应性受试者和10名非特应性受试者进行了利福霉素成分的皮肤点刺试验。尽管普拉茨-屈斯特纳（P-K）试验是一种旧的检测方法，但我们也对其中一名患者的配偶进行了该试验，以显示被动转移和IgE介导的机制。
对患者进行的空气过敏原、乳胶和利福霉素成分（利福霉素SV除外）的皮肤试验过敏评估均为阴性。患者对利福霉素SV的点刺试验呈阳性，而对照受试者为阴性。P-K试验呈阳性。
两例病例报告支持存在对利福霉素SV的IgE介导反应。利福霉素SV引起的IgE介导的过敏反应似乎极为罕见。
