Chiba T, Tanaka K
Department of Neurobiology, Chiba University School of Medicine, Japan.
J Auton Nerv Syst. 1998 Jul 15;71(2-3):139-47. doi: 10.1016/s0165-1838(98)00068-x.
The correlations between nitric oxide synthase (NOS)-immunoreactive (NOS-ir) preganglionic sympathetic neurons (PSNs) in the thoracic spinal cord and the neurons in the superior cervical ganglia (SCG) were studied with special reference to target specificity. NOS-ir neurons were distributed in the intermediate gray of the spinal cord and most numerous in the intermediolateral subnucleus of the PSNs. NOS-ir PSNs received direct synaptic contacts from tyrosine hydroxylase-ir, 5-hydroxytryptamine-ir, gamma-amino butyric acid-ir, and phosphate-activated glutaminase-ir axons. A majority of PSNs projecting to SCG were NOS-ir but some were NOS-negative. Large SCG neurons surrounded by a dense network of NOS-ir axons from PSNs projected to the submandibular salivary gland. NPY-ir small SCG neurons devoid of NOS-ir PSN innervation projected to blood vessels. SIF cells in the SCG were NOS-negative and provided with a meshwork of NOS-ir axons. The present results suggest a subpopulation of SCG neurons may be concerned with a distinct functional category in the rat under the influence of NOS-ir preganglionic sympathetic neurons.
研究了胸段脊髓中一氧化氮合酶（NOS）免疫反应性（NOS-ir）节前交感神经元（PSN）与颈上神经节（SCG）中神经元之间的相关性，特别关注靶标特异性。NOS-ir神经元分布在脊髓中间灰质中，在PSN的中间外侧亚核中数量最多。NOS-ir PSN接受来自酪氨酸羟化酶-ir、5-羟色胺-ir、γ-氨基丁酸-ir和磷酸激活谷氨酰胺酶-ir轴突的直接突触联系。投射到SCG的大多数PSN是NOS-ir，但有些是NOS阴性。被来自PSN的NOS-ir轴突密集网络包围的大型SCG神经元投射到下颌下唾液腺。缺乏NOS-ir PSN支配的NPY-ir小型SCG神经元投射到血管。SCG中的SIF细胞是NOS阴性，并具有NOS-ir轴突网络。目前的结果表明，在NOS-ir节前交感神经元的影响下，SCG神经元的一个亚群可能与大鼠中一个独特的功能类别有关。
