Shimokawa A, Kunitake T, Takasaki M, Kannan H
Department of Anesthesiology, Miyazaki Medical College, Kiyotake, Japan.
J Auton Nerv Syst. 1998 Aug 6;72(1):46-54. doi: 10.1016/s0165-1838(98)00084-8.
The effects of pentobarbital sodium, chloralose, and urethane on sympathetic nerve activity and arterial baroreceptor reflex were examined using rats chronically instrumented for recordings of blood pressure (BP), electrocardiogram and renal sympathetic nerve activity (RSNA). Pentobarbital sodium (30 mg/kg, i.v.) produced a decrease in BP with a transient decrease in heart rate (HR) and no change in RSNA. Chloralose (50 mg/kg, i.v.) also caused a decrease in BP and no change in HR and RSNA until a later increase in HR and RSNA, while urethane (800 mg/kg, i.v.) increased BP, HR, and RSNA. Baroreceptor reflex function was assessed by constructing a logistic function curve compiled from data obtained by intravenous infusion in increasing doses of phenylephrine and sodium nitroprusside. Both pentobarbital sodium and chloralose administration decreased the gain of baroreceptor reflex control of both HR and RSNA. Urethane also decreased the gain of baroreceptor reflex control of HR but elicited no change in that of RSNA. These results suggest that different intravenously administered anesthetics affect the peripheral sympathetic outflows in qualitatively and quantitatively different manners.
使用长期植入仪器以记录血压（BP）、心电图和肾交感神经活动（RSNA）的大鼠，研究了戊巴比妥钠、氯醛糖和乌拉坦对交感神经活动和动脉压力感受器反射的影响。静脉注射戊巴比妥钠（30mg/kg）导致血压下降，心率（HR）短暂降低，而RSNA无变化。静脉注射氯醛糖（50mg/kg）也导致血压下降，HR和RSNA在后期HR和RSNA增加之前无变化，而静脉注射乌拉坦（800mg/kg）使BP、HR和RSNA升高。通过构建逻辑函数曲线来评估压力感受器反射功能，该曲线由静脉注射递增剂量的去氧肾上腺素和硝普钠所获得的数据编制而成。戊巴比妥钠和氯醛糖给药均降低了压力感受器对HR和RSNA的反射控制增益。乌拉坦也降低了压力感受器对HR的反射控制增益，但对RSNA的反射控制增益无影响。这些结果表明，不同的静脉麻醉药以定性和定量不同的方式影响外周交感神经输出。
