Gosepath J, Welkoborsky H J, Mann W
Universitäts HNO-Klinik Mainz.
Laryngorhinootologie. 1998 Aug;77(8):429-33. doi: 10.1055/s-2007-997003.
Paragangliomas (glomus tumors) of the head and neck are rare tumors, arising from the paragangliomatous tissue either of the carotid region or the jugular or the tympanic region. This study was conducted to investigate the possible differences in the tumor biology of these lesions depending on their site of origin.
Nineteen specimens (10 jugulotympanic and 9 carotid glomus tumors) were investigated by quantitative DNA measurements and immunohistochemical assessment of proliferation markers (PCNA, Ki67), oncogenes (p53, nm23), different cell surface antigenes (CD44 4/5 and 6, CD54, CD106), and bcl 2 as a marker for apoptosis.
Depending on the location of the tumors these measurements revealed significant differences in tumor biology with higher proliferation scores and a higher number of aneuploid tumors in those of the carotid region, suggesting a more aggressive behavior compared to those of the jugulotympanic region.
The results also indicate a difference between the two groups in the risk of developing metastases or recurrent disease. They generally help to enhance our understanding of the biology of paragangliomas of the head and neck.
头颈部副神经节瘤（球瘤）是罕见肿瘤，起源于颈动脉区、颈静脉区或鼓室区的副神经节组织。本研究旨在调查这些病变因其起源部位不同在肿瘤生物学方面可能存在的差异。
通过对19个标本（10个颈静脉鼓室球瘤和9个颈动脉体瘤）进行DNA定量检测以及对增殖标志物（PCNA、Ki67）、癌基因（p53、nm23）、不同细胞表面抗原（CD44 4/5和6、CD54、CD106）和作为凋亡标志物的bcl 2进行免疫组化评估。
根据肿瘤的位置，这些检测揭示了肿瘤生物学方面的显著差异，颈动脉区肿瘤的增殖分数更高且非整倍体肿瘤数量更多，表明与颈静脉鼓室区肿瘤相比，其行为更具侵袭性。
结果还表明两组在发生转移或复发疾病的风险方面存在差异。它们总体上有助于增强我们对头颈部副神经节瘤生物学的理解。
